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diagnosis hematology differential oncology hemolysis hemolytic leukemia causes chronic extravascular intravascular lymphocytic agglutinin algorithm autoimmune bandemia cbc cold disease hemeonc
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic Anemia ... (AIHA) Pathophysiology ... Autoimmune #Hemolytic #Anemia ... #Pathophysiology ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
• Cold AIHA ... • Drug-induced AIHA ... • Sickle cell ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... - Autoimmune (AIHA ... ) (e.g. lupus, CLL ... - Autoimmune (AIHA ... #anemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... ) CLL Symptoms: ... mosquito bites CLL ... /Cytopenias • AIHA ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... Hypogammaglobulinemia • Warm AIHA ... workup #oncology #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... Defects: Sickle cell ... anemia, Thalassemias ... Differential #Diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... cytopenias (ITP, AIHA ... marrow failure with anemia ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... • hemolytic anemia ... disease #hemolytic #anemia ... #hematology #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Evans • ITP • Cl-NH ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Left Shift: • Cell ... precursors" • Stab cell ... neutrophil #WBC #CBC #hematology ... #pathophysiology
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