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hematology nephrology differential treatment blood cancer mds myelodysplastic product reactions algorithm anemia aplastic apml classification differentiation emergencies gitelman hemeonc hemophagocytic
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... of breath • Neurologic ... neutrophil count < 500 cells ... renal failure • Hypocalcemia ... #differential #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... old, ~10,000 new cases ... Myelodysplastic #Syndrome ... #hematology #oncology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Framework and Management ... Summary Causes ... kidney tubular cells ... #Management #causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... only if no clear cause ... Drives K+ into cells ... #Diagnosis #Management ... Treatment #potassium #nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Lysis of tumor cells ... hydration - Hyperkalemia ... #TLS #diagnosis ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Out Secondary Causes ... #diagnosis #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... Differentiation #Syndrome ... #management #hematology ... #oncology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Inherited (AR) hypokalemic ... apical membrane of cells ... #diagnosis #nephrology ... #management #pathophysiology ... #Hypokalemia
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... lymph node biopsy (diagnostic ... Hodgkins #lymphoma #diagnosis ... classification #hematology ... #oncology #management
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