79 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... autoinflammatory diseases ... splenomegaly • Hepatic ... #diagnosis #management ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
+++ (Plt, Hb), Hepatic ... Drugs, Unknown cause ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Severe Liver Disease ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... = funny-shaped cells ... old, ~10,000 new cases ... only curative treatment ... #treatment #hematology
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
Hepatic Encephalopathy ... Diagnosis and Management ... rule out other causes ... over course of disease ... #treatment #hepatology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... #Syndrome #Treatment ... #management #pharmacology ... #rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Diagnosis and Management ... thrombocythemia), Autoimmune disease ... adsorption onto cancer cells ... Syndrome #Diagnosis #Management ... #treatment #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... Alcohol-related liver disease ... , Hepatic ischaemia ... presentation: Hepatic
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... screening for disease ... with established disease ... normal in mild cases ... #treatment #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
diagnosis and treatment ... of liver disease ... including liver and hematologic ... hemochromatosis; HIC, hepatic ... algorithm #diagnosis #management