21 results
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... #dermpath #dermatology ... #semiology #signs ... lesions #diagnosis #clinical ... pathology #lesions #differential
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... various inflammatory cells ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Summary Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... - Erosions and crusts ... #dermatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... infiltration) Differential ... Maternal Support - Critical ... #pathophysiology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... purpura: Strong sign ... Multinucleated giant cells ... tract, and often causes ... Diagnosis #Rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... WBC >100k, + lab signs ... Lysis of tumor cells ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Release from blast cells ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
combination of the clinical ... lateral sclerosis Pathophysiology ... - Causes progressive ... conditions listed in differential ... neurology #diagnosis #management
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
Pathogenesis and clinical ... hearing loss, nausea ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology