18 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... • Induce blast cell ... initiation • Differential ... • Steroids: IV ... #management #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
CBC • Confirm: Flow ... microglobulin Treatment ... • Richter’s Syndrome ... Transform to DLBCL, PML ... leukemia • Sezary syndrome
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... blood count with differential ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
ARVs can have low ... The clinical syndrome ... and with low CD4 ... Treatment: • HAART ... dementia #AIDS #Neurology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
- HIV • Immune ... immunodeficiency virus (HIV ... aplastic anemia Treatment ... may result from low ... #diagnosis #management
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
to infections (HPV ... (Goodpasture's syndrome ... Renal #Transplant #differential ... #blood #urine #management ... #treatment #nephrology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
/ AIDS - Differential ... Antimicrobial treatment ... status, and focal neurologic ... CNS #Infections #differential ... InfectiousDiseases #Neurology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
originate from a low-grade ... Cold Agglutinin Syndrome ... Mycoplasma, EBV, HIV ... younger pts) Differential ... sensitize red blood cells
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Framework and Management ... Infection - Viral (HIV ... kidney tubular cells ... #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Diagnosis and Management ... Redistribution: Acidosis, Cell ... acidosis) • Low ... Drives K+ into cells ... #nephrology #K