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diagnosis hematology treatment differential syndrome activetb chronic cll hemeonc latenttb lymphocytic lymphoma mds myelodysplastic rheumatology tb tuberculosis acute algorithm all
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Pseudotumor - Infectious ... History of Bleeding, Infection ... Reed-Sternberg Cells ... Biopsy • Hodgkin's ... Causes #Hematology #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... involved) • No leukemic ... Etiology: - Infections ... type (B cell, T cells ... NonHodgkins #comparison #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... cells. ... History of EBV infection ... classification #hematology #oncology ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... weeks without infection ... or basket cells ... , Hodgkin’s lymphoma ... diagnosis #workup #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... : Granulocytic cells ... bruising, bleeding, infection ... #Hematology #Oncology
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
Infection-Related ... - Adult T-cell Leukemia ... • EBV - NHL, Hodgkin's ... @drkeithsiau #Infection ... Associations #Cancers #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... = funny-shaped cells ... risk-stratification • Risks: infection ... transformation to acute leukemia ... treatment #hematology #oncology
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Lymphoblastic Leukemia ... Lymphoblastic #Leukemia ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Most common leukemia ... lymphocytes, smudge cells ... Complications: 1) Infection ... #oncology #hematology ... hemeonc #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Activation of CD8 T cells ... Phagocytosis of blood cells ... Hemopathies+++: Hodgkin ... Lymphohistiocytosis #diagnosis #management
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