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diagnosis hematology differential oncology mds myelodysplastic aplastic bruising common cvid cytokine depressed elevatedmcv hemeonc hemophagocytic hhv8 hlh hypogammaglobulinemia immunodeficiency immunology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Causes of Depressed / Lethargic Newborn - Differential Diagnosis Algorithm Maternal Related: • Drugs (Ex. SSRI) •
Causes of Depressed ... Respiratory Distress Syndrome ... Sepsis Other: • Anemia ... #Causes #Peds # ... Pediatrics
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - Fanconi anaemia ... - Aplastic anaemia ... Purpura #Bruising #Causes ... #peds #pediatrics
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... infections/fevers • Thrombocytopenia ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... #Causes #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... platelet count (thrombocytopenia ... skin that are caused ... IDUS) • Immune Thrombocytopenia ... #diagnosis #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
specifically immune thrombocytopenia ... autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... - infiltrates (anemia ... , thrombocytopenia ... • Tumor lysis syndrome
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
Inflammatory Cytokine Syndrome ... KICS) Working Case ... abnormalities: Anemia ... , Thrombocytopenia ... Kaposi #diagnosis #management
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