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diagnosis hematology oncology chronic cll lymphocytic mds myelodysplastic treatment aplastic asplenia blood bloodsmear causes clinical coagulation dic disseminated hemeonc howell
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... develop leukostasis syndrome ... - infiltrates (anemia ... smear: Blasts ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... smear: Smudge cells ... • Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Diagnosis: • Peripheral ... smear → small rnature-appearing ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... hemeonc #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... transformation to acute leukemia ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Smear: • Dysplastic ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... blood smear • ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... virus (EBV) • Leukemia ... ) Labs: • Peripheral ... #oncology #hematology ... #diagnosis #management
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral ... blood smears the ... thalassemia, and leukemia ... #Clinical #Path ... BloodSmear #Blood #Smear
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... D-Dimer: ↑ • Peripheral ... smear: Schistocytes ... causes #treatment #management ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... neuropathy • Peripheral ... Pulmonary amyloidosis, PAH ... #Rheumatology # ... Diagnosis #Management
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