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diagnosis hematology leukemia chronic cll hemeonc lymphocytic myelodysplastic algorithm aplastic autoinflammatory differential e1 hemophagocytic hlh lymphohistiocytosis myelodysplasia platelets sjogrens somatic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... Smear: • Dysplastic ... blood smear • ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... #oncology #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... Abnormalities: macrocytic anemia ... myelodysplastic syndrome ... myelodysplastic syndrome ... including peripheral
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm Peripheral ... Smear concerning ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... Matthew Ho, MD
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Diagnosis: • Peripheral ... smear → small rnature-appearing ... Lauren Banaszak, MD ... Lymphocytic #Leukemia #oncology ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... smear: Smudge cells ... • Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... SLE • Mikulicz syndrome ... enlargement Sjogren's Syndrome ... #Sjogrens #Syndrome ... #Rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... patients with the HLH syndrome ... (often termed MAS-HLH ... Macrophage Activation Syndrome ... - Cytopenias (anemia
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