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hematology oncology management causes workup clinical hemolytic atlas chronic classification disorders hemeonc hemolysis leukemia lymphocytic mds morphology myelodysplastic rbc table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... sensitize red blood cells ... #hematology #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... : Cold autoimmune ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... - Drugs (Beta lactam ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Autoimmune: Warm AIHA, Cold ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate ... #Diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... - Sickle cell anemia ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... • Sickle cells ... Consider sickle cell ... Agglutination - Cold
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... : 70 years old, ... cytopenias (usually anemia ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... Lymphocytic #Leukemia #diagnosis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... #LDH #Lactate ... #diagnosis #Laboratory
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... #hemeonc #diagnosis
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