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causes dermatology algorithm oncology clinical management hepatology anemia syndrome rash rheumatology skin skinrash table workup disorders hemolytic liver myelodysplastic nails
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... criteria for 1) hematologic ... conditions - multiple myeloma ... peripheral blood myeloid ... cells NEJM Review
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... Features of hematologic ... predominant immature cells ... #hematology #WBC
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework Hematologic & Vascular: • Multiple myeloma & Acute leukemia (plasma cells
Hyperammonemia - Differential ... Diagnosis Framework ... Hematologic ... : • Multiple myeloma ... leukemia (plasma cells
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... lymphoma, multiple myeloma ... adsorption onto cancer cells ... Management #treatment #hematology ... #differential
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - Differential ... Diagnosis Platelet ... Myelofibrosis • Chronic Myeloid ... #Diagnosis #causes ... #Platelets #hematology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... Diagnosis • ... lymphoma, melanoma, myeloma ... #Diagnosis #causes ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... Diagnosis Algorithm ... Polycythemia • Multiple Myeloma ... #Diagnosis #Algorithm ... #Causes #Hepatology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... similarly to mast cells ... #Diagnosis #causes ... #hematology #basophils
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Formation • Multiple Myeloma ... Macrocytosis, Target Cells ... #Causes #Hematology
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