12 results
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... Even the pathology ... polyangiitis, and Castleman
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
POEMS syndrome, myeloma ... Leah Willis via ... #differential #diagnosis ... #causes #neurology
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook

Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy
Presentation:
Bell's Palsy - Diagnosis ... ear/skull base pathology ... /temporal bone pathology ... #Palsy #Diagnosis ... Management #Treatment #Neurology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
et diutinum Neurologic ... POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... component+neuropathy+Castleman ... #Differential #Diagnosis
Some of the techniques used for Antenatal Diagnosis

Amniocentesis 
 - Chromosome/micro-array and DNA analysis 
 -
for Antenatal Diagnosis ... Fetal infection serology ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... Antenatal #Testing #Diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
amyotrophy with the pathologic ... - Microglial cells ... are the immune cells ... between nerve cells ... Lateral #Sclerosis #neurology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Diagnosis? ... patients with EMD myeloma ... Diagnostic Evaluation ... IFE, FLC assay Pathology ... • Multiple myeloma