12 results
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma ... #oncology
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... Even the pathology ... polyangiitis, and Castleman
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... POEMs syndrome, Castleman's ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... Management Summary myelo ... = funny-shaped cells ... 10,000 new cases diagnosed ... treatment #hematology #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... component+neuropathy+Castleman ... #Differential #Diagnosis ... #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
to IgM multiple myeloma ... marrow plasma cells ... to light-chain myeloma ... Significance #hematology #diagnosis ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... • Neutrophils (myeloid ... AML (Acute Myeloid ... Leukemia #Hematology #Oncology ... #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... , or all three myeloid ... , and the cells ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma