63 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... including peripheral blood ... myeloid cells ... NEJM Review: https
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... , Liver diseases ... Hemolytic uremic syndrome ... #differential #hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... : Sickle cell disease ... Bite cells: G6PD ... #Peripheral #Blood ... Smear #Analysis #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... cells, red blood ... cells - red blood ... cells, white blood ... #diagnosis #hematology
Sickle cells
These photos show sickle cells on peripheral blood smears. In the left photo target cells
photos show sickle ... blood smears. ... to sickle cell disease ... thalassemia, and HbSC disease ... Path #BloodSmear #Blood
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... : Acute blood loss ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... and Associated Syndromes ... • Hyalinizeä blood ... Diffuse plasma cells ... Pathogenesis "IL6 syndrome
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Algorithm Normal Blood ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... • Liver Disease ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... , Drugs, Liver Disease ... Electrolytes: Wilson's disease ... - Peripheral Blood ... Differential #Diagnosis #hematology
Some of the techniques used for Antenatal Diagnosis

Amniocentesis 
 - Chromosome/micro-array and DNA analysis 
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— PCR Fetal blood ... serology - Fetal blood ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome