10 results
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
and Plasma-Cell Leukemia ... A peripheral-blood ... revealed 25% plasma cells ... Plasmacytomas #PlasmaCell #Leukemia ... #Smear #NEJM
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blasts in the peripheral ... blood smear or ... - Blood and Bone ... develop leukostasis syndrome ... • Tumor lysis syndrome
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... leukopenia) Peripheral ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... differential • Peripheral
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... or basket cells ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... • Sezary syndrome
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... Carpal tunnel syndrome ... Increased plasma cells ... and stocking" peripheral ... Diagnostic Testing Blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... hematopoietic stem cells ... including peripheral ... blood myeloid cells ... NEJM Review: https
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... virus (EBV) • Leukemia ... anemia) Labs: • Peripheral ... result from low blood ... hematology #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
promyelocytic leukemia ... ABO incompatible blood ... D-Dimer: ↑ • Peripheral ... Schistocytes, helmet cells ... causes #treatment #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... neuropathy • Peripheral ... 27% for CNS and peripheral ... PE, Pulmonary amyloidosis ... Rheumatology #Diagnosis #Management
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral ... blood smears the ... in the right photo ... thalassemia, and leukemia ... Path #BloodSmear #Blood