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hematology differential management oncology syndrome anemia arthritis classification joint pain aion anteriorischemicopticneuropathy apml approach blood causes chronic cll differentiation eosinophil
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... evaluation or workup ... /µL Workup • Screen ... #diagnosis #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... or λ), Smudge Cells ... Amy Chung, MD, MSc ... #hematology #Markers ... #Algorithm
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
- Differential Diagnosis ... Algorithm Infection ... Polycythemia vera Acute ... pancytopenia, blast cells ... #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Algorithm Hodgkin ... pattern of spread, B symptoms ... Treated Like Acute ... Classification #pathophysiology ... #Hematology #Diagnosis
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... High in acute blood ... (BM) ablative disorders ... #Diagnosis #Workup ... #Hematology #Microcytic
Anterior ischemic optic neuropathy (AION) - Recognition of giant cell arteritis (GCA) 1) Is visual loss caused
Definition: acute ... ischemic disorder ... GiantCellArteritis #GCA #Rheumatology ... Ophthalmology #Diagnosis ... #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... cells - Consider ... Consider RBC membrane disorder ... #Algorithm #workup
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... Lysis of tumor cells ... Syndrome #TLS #diagnosis ... #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... lymphoproliferative disorders ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Release from blast cells ... • Rare: DAH, acute ... : >3 symptoms, or ... #management #hematology
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