8 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Pathophysiology ... • Steroids: IV ... management #hematology #oncology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
dementia Pathophysiology ... The clinical syndrome ... Treatment: • HAART ... disorder #dementia #AIDS ... #Neurology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
/ AIDS - Differential ... Antimicrobial treatment ... status, and focal neurologic ... Demyelinating disease caused ... differential #diagnosis #AIDS
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Summary Acute AIDP ... Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Campylobacter jejuni - HIV ... #neurology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... Treat underlying cause ... “big & sticky” cells ... IV bisphosphonates ... (~20 %) and APL
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... of HIV/AIDS patients ... be present: • AIDS ... increase in CD4+ cells ... #Inflammatory #Syndrome
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Causes progressive ... diagnosis column Treatment ... motor neurons - IV ... Lateral #Sclerosis #neurology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... • Infectious causes ... simplex virus, HIV ... Transverse Myelitis Treatment