25 results
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... Natural Killer Cells ... cell activity #Inflammatory ... #Inflammation #pathophysiology ... #immunology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Inflammatory mechanism ... the release of inflammatory ... #asthma #pathophysiology ... #inflammatory # ... immunology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
production of inflammatory ... Recruitment of inflammatory ... cells • ANS activation ... #Anaphylaxis #pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... cells recruited ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
mutation) that alter inflammatory ... yrs old; F>M Signs ... Anemia - Giant cells ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Signs of immunodeficiency ... from precursor cells ... humoral immunity Signs ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
activating cellular inflammatory ... vascular endothelial cells ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... cytokines -> localized inflammatory ... removal of these cells ... Manifestations #pathophysiology ... #diagnosis #signs
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... Lysis of tumor cells
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... can become pro-inflammatory ... of UMN and LMN signs ... EMG: LMN Signs in ... diagnosis column Treatment