37 results
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Particular CD4+ Th cells ... harmful -> Th Cells ... macrophages, mast cells ... #Immunology #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... plasma cells that ... complexes bind to mast cells ... • Inflammatory cells ... #Immunology #pathophysiology
Bell's palsy
There are many different causes of Facial Nerve Palsy. However, the commonest
cause of unilateral facial
Bell's palsy There ... variety known as Bell's ... - Ptosis #Bells ... #Signs #Symptoms ... #Diagnosis
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... exposure to a likely allergen ... exposure to known allergen ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
with cytotoxic T cells ... natural killer cells ... antigen - TH1 cells ... Classification #Pathophysiology ... #Allergy #Diagnosis
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
surfaces of body cells ... body cell -> B-Cells ... foreign -> B-cells ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... Eosinophilia, 500-1,500 cells ... Hypereosinophilia, >1,500 cells ... causes are asthma, allergy ... #Differential #diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
40% of patients diagnosed ... maturation of B cells ... from precursor cells ... CD19+) and plasma cells ... #immunology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
old; F>M Signs/Symptoms ... Anemia - Giant cells ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Reed-Sternberg (RS) Cells ... Lymphocyte - 5% RS cells ... (LP) tumour B cells ... pattern of spread, B symptoms ... Classification #pathophysiology