12 results
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Dysplasias • (e.g ... Panhypopituitarism Treatment ... Metabolism Error • Immunologic ... Anorexia Nervosa • CNS ... Tumors (e.g.
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Lipid mediators (e.g ... Other mediators (e.g ... inflammatory mediators (e.g ... #Anaphylaxis #pathophysiology ... #immunology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Treatment:
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... Diagnosis #Management #treatment ... #hematology #differential
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... Lysis of tumor cells ... unless worrisome EKG ... diagnosis #management #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Pathophysiology ... Prednisone 5mg/kg ... diagnosis #management #hematology ... #oncology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
nervous system (CNS ... underlying disease (eg ... • Infection (eg ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... , breast bone, pelvis ... and lower jaw Treatment ... antiinflammatory properties e.g ... #Rheumatology #
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... Virologic and immunologic ... increase in CD4+ cells ... pleural effusions, CNS ... #Inflammatory #Syndrome
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
• Petechiae Immunologic ... Cholesterol emboli syndrome ... ↑ ESR, CRP • EKG ... hematuria, + RF Treatment ... Differential #Diagnosis #cardiology