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diagnosis hematology neurology differential oncology symptoms workup anesthesia anesthesiology causes checklist hemophagocytic hlh lymphohistiocytosis mds myelodysplastic sclerosis acquired activation aids
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Triggers: ATRA treatment ... Pathophysiology ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
WBC >100k, + lab signs ... Lysis of tumor cells ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... adsorption onto cancer cells ... vonWillebrand #Syndrome ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cell transplant is ... only curative treatment ... #treatment #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
Diagnosis and Management ... present, symptoms, signs ... transformation into AML ... • Treatment is ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... marrow studies Treatment ... progression to AML ... Immunosuppressive treatment ... #diagnosis #hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is ... Serologic and EMG ... test - Cogan sign ... - Peek sign ... Gravis #diagnosis #management
Syncope is a sudden, transient loss of consciousness, which is thought to be secondary to cerebral
carotid sinus syndrome ... further guide management ... orthostatic vital sign ... and an initial ECG ... The treatment strategy
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL is ... Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... Transform to DLBCL, PML
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