31 results
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Classification Class ... depolarization in fast AP cells ... depolarization in slow AP cells ... depolarization in slow AP cells ... #cardiology #pharmacology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
++ influx into cells ... inotropy) ACCP Cardiology ... Vaughan #Williams #Pharmacology ... #pathophysiology ... #cardiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... increases out of cells ... ++ influx into cells ... Antiarrhythmics #Pharmacology ... #pathophysiology
Drug-Induced Edema
Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
release from mast cells ... Edema #Medication #Causes ... #Differential #Pharmacology ... #Pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Pathogenesis and clinical ... exposure to allergen causes ... harmful -> Th Cells ... macrophages, mast cells ... Allergy #Immunology #pathophysiology
Tree in Bud Sign
The Tree-in-Bud sign represents Endobronchial spread in a linear branching pattern and centrilobular
actually seen in all causes ... pneumonia, congenital causes ... Sign #diagnosis #clinical ... #radiology #ChestCT ... #pathophysiology
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
the long bone or pelvis ... accounts for —9096 of cases ... Pathophysiology ... FES is a clinical
Torsades de Pointes (TdP): Pathogenesis and Clinical Findings

Polymorphic ventricular tachycardia initiated by PVC in the setting
Pathogenesis and Clinical ... TdP #Diagnosis #pathophysiology ... #cardiology #causes
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Pathogenesis and clinical ... macrophages, HLA class ... -> Helper T cells ... Abs coat mast cells ... Rhinitis #Rhinorrhea #pathophysiology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Pathogenesis and clinical ... maturation of B cells ... from precursor cells ... to produce all classes ... Agammaglobulinemia #XLinked #pathophysiology