11 results
diagnosis hematology oncology differential causes hemeonc acidosis adultonset anemia aplastic chronic classification cll dermatology differentiation disease elevation emergencies hemophagocytic hlh
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Triggers: ATRA treatment ... HoTN, edema and effusions ... #management #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... • Pulmonary: pleural ... effusion, infiltrates ... Disease #diagnosis #management ... #treatment #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ducts Clinical ... thickening or effusion ... phenomenon (16%) MSK ... #Rheumatology # ... Diagnosis #Management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... microglobulin Treatment ... • Richter’s Syndrome ... Transform to DLBCL, PML ... leukemia • Sezary syndrome
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Dermatomyositis Clinical ... decreased renal perfusion ... kidney tubular cells ... Differential #Diagnosis #Management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... , breast bone, pelvis ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... initiation Clinical ... pulmonary infiltrates, pleural ... effusions, CNS ... Differential #Diagnosis #Management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
e.g., uptake by cells ... / hypoxemia -> focus ... - shock->treatments ... before beginning treatment ... - Compartment syndrome
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
“big & sticky” cells ... : - Seen with AML ... (~20 %) and APL ... opacities, SOB, pleural ... effusions - Treatment
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