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diagnosis management hematology neurology bowel differential gastroenterology hemeonc irritable leukemia sclerosis aids als amyotrophic anemia aplastic associated caudaequina chronic cll
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... Diagnosis: >3 symptoms ... management #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• 75% of ALL is ... count ↑ PLT • ↑ PBS ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Irritable Bowel Syndrome (IBS) - Management Global IBS Symptoms: - Limited trial low FODMAP diet
Irritable Bowel Syndrome ... Global IBS Symptoms ... intestinal epithelial cells ... peristalsis - 5-HT4 (Serotonin ... gastroenterology #treatment
Irritable Bowel Syndrome (IBS) - Diagnosis and Management Summary Diagnosis: • Use a positive diagnostic strategy with
Irritable Bowel Syndrome ... for diagnosis Treatment ... intestinal epithelial cells ... peristalsis - 5-HT4 (Serotonin ... Irritable #Bowel #Syndrome
Rapid, increasing signs of extrapyramidal symptoms (EPS) is an important key feature of NMS. EPS, associated
Rapid, increasing signs ... extrapyramidal symptoms ... and white blood cells ... #Diagnosis #Serotonin ... #Syndrome #NMS
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... WBC >100k, + lab signs ... : • Pathophysiology ... Lysis of tumor cells
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... / Symptoms / Complications ... #MSK #pathophysiology ... #signs
Fat Embolism Syndrome Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... the long bone or pelvis ... Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Refeeding Syndrome ... PO4 and Mg into cells ... Constipation - MSK ... #diagnosis #pathophysiology ... #symptoms #signs
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... “big & sticky” cells ... → no immediate treatment ... : - Seen with AML ... (~20 %) and APL
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