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diagnosis differential nephrology cancer management acute causes emergencies injury kidney oncologic tls classification hemeonc hyponatremia leukostasis lysis rhabdomyolysis tumorlysis
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor ... Lysis Syndrome ... Clinical TLS: • AKI ... #TumorLysis #Syndrome ... diagnosis #management #oncology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Kidney Injury (AKI ... change disease • Hematologic ... malignancies Treatment ... #Cancer #Oncology ... Classification #Nephrology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... of breath • Neurologic ... neutrophil count < 500 cells ... EMERGENCIES: Tumor ... renal failure • Hypocalcemia
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... Pre-Renal: • Hypovolemia ... Abdominal Compartment Syndrome ... • Obstruction (Tumor ... #causes #algorithm
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
fever - ACS, AKI ... organ damage • Treatment ... cells releasing ... hydration - Hyperkalemia ... diagnosis #management #hematology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... declines > ALT) • AKI ... + myoglobin AKI ... kidney tubular cells ... #nephrology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... antibiotics TLS (tumor-lysis ... syndrome): - Hematologic ... “big & sticky” cells ... → no immediate treatment
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Differential Diagnosis Algorithm ... appropriate • Hypovolemia ... capillary leak syndrome ... head and neck tumors ... #nephrology #oncology
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