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diagnosis management differential classification cancer chronic cll hodgkins lymphocytic lymphoma mds myelodysplastic tls acute aki algorithm anemia aplastic apml behcet
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
change disease • Hematologic ... malignancies Treatment ... lysis syndrome ... #AKI #Cancer #Oncology ... Classification #Nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... Lysis Syndrome: ... of tumor cells ... #Lysis #Syndrome ... diagnosis #management #hematology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... lymphoma & Acute leukemia ... malignancies Treatments ... #Lysis #Syndrome ... #TLS #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... transformation to acute leukemia ... only curative treatment ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
: Granulocytic cells ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... #Hematology #Oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... of breath • Neurologic ... neutrophil count < 500 cells ... EMERGENCIES: Tumor ... Lysis Syndrome:
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... • Richter’s Syndrome ... • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... patients with minimal tumor ... lymphocytes, smudge cells ... #oncology #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... extranodal) - Tumor ... ALL) • Solid Tumors ... NonHodgkins #comparison #oncology ... #differential #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
predominant (LP) tumour ... Responsive to Treatment ... Treated Like Acute Leukemias ... growth, response to treatment ... pathophysiology #Hematology
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