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diagnosis oncology causes management algorithm chronic classification cll lymphocytic mds myelodysplastic thrombocytosis acquired agglutinin aplastic cold disease elevatedmcv erythematosus gap
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Chronic Myelogenous Leukemia ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Chronic inflammatory disorders ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... transformation to acute leukemia ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... • Neutropenia, anemia ... microglobulin Treatment ... • Sezary syndrome ... workup #oncology #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... adsorption onto cancer cells ... vonWillebrand #Syndrome ... Diagnosis #Management #treatment ... #hematology #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... blood count with differential ... #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
in adults • Disorder ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... - Differential ... Responsive to Treatment ... Treated Like Acute Leukemias ... pathophysiology #Hematology
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