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diagnosis hematology treatment all anemia aplastic apml cancer differential differentiation emergencies leukemia lymphoblastic mds myelodysplastic oncologic peds sarcoidosis signs symptoms
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... marrow) -dys- (abnormal ... = funny-shaped cells ... transformation to acute ... treatment #hematology #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... neutrophil count < 500 cells ... mm3 • Single oral ... : Tumor Lysis Syndrome ... Hyperuricemia • Acute
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Standard-Risk Acute ... mercaptopurine, Weekly oral ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... 500 mg QD until normal ... APML #diagnosis #management ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... (MDS) (normal or ... megakaryocytes and a normal ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... tissue: Epithelioid cells ... ), liver (pain/abnormal ... : ACUTE, fever, ... Sarcoidosis #Diagnosis #Management
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