35 results
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
& inflammatory cells ... Clinical: • Disease ... • Neurologic: Bell's ... dysrhythmias • Ophthalmologic ... #Sarcoidosis #Diagnosis
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... Syndrome - Diagnosis ... and Management ... thrombocythemia), Autoimmune disease ... adsorption onto cancer cells
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
- Differential Diagnosis ... History • Bite cells ... Deficiency • Sickle cells ... spherocytosis Acquired ... malignancy, autoimmune disease
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Phagocytosis of blood cells ... Purtilo (XLP) Acquired ... • Autoimmune diseases ... #management #treatment
Graft-Verus-Host Disease (GVHD) - Quick Reference Sheet
Multisystem disorder that is a common complication of allogeneic hematopoietic
Graft-Verus-Host Disease ... occurs when immune cells ... GraftVerusHost #Disease ... CheatSheet #Transplant #Diagnosis ... #Overview #Management
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
for dx - T-cells ... chronic LPD of NK cells ... but cells are NK ... cells (sCD3-, no ... hemepath #pathology #diagnosis
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma Diagnosis ... and Management ... demineralization) • Renal disease ... marrow plasma cells ... #Management #oncology
Hansen's Disease (Leprosy)
 • Transmission - not completely understood, ?nasal droplets
 • Symptoms appear ~5 years
Hansen's Disease ... do not contract disease ... cytoplasm, plasma cells ... #Leprosy #diagnosis ... #management #treatment
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Reed-Sternberg cells ... lymph node biopsy (diagnostic ... number of sites of disease ... hematology #oncology #management
Lyme Disease - Diagnosis and Management Summary

Lyme Disease Epidemiology:
- Spirochete
- Reservoir: small mammals & birds
- Transmitted
Lyme Disease - Diagnosis ... and Management ... Meningo-encephalitis - Bell ... Diagnosis: 1. ... #Diagnosis #Management