14 results
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pathophysiology 1) ... works by directly ... intracellular calcium causes ... - Hyperkalemia ( ... , in states of hypokalemia
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... as necessary at 1- ... level teaspoons) 1- ... ); nausea, vomiting ... of aspiration #Potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... discrete buckets: 1. ... #Causes #workup ... #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... acidosis (type 1 ... #causes #nephrology ... #potassium
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Algorithm Acidosis ... #Differential #Algorithm ... #Diagnosis #Causes ... #Workup #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
: • Digoxin ... Increased K Intake: 1. ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
: • Digoxin ... Increased K Intake: 1. ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... antagonism • alpha-1 ... agonism • Digoxin ... IntercellularShift #Nephrology ... #Causes
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing
Common causes: 
 • Renal parenchymal disease
Causes of Secondary ... (correction of hypokalemia ... Oral sodium loading ... syndrome - Overnight 1- ... #Screening #Workup
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Calcineurin inhibitors, Digoxin ... reabsorption) Workup ... 5-10U reg IV + 1- ... Management #Treatment #potassium ... #nephrology #K