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differential management anemia product transfusion vasculitis agglutinin algorithm classification cord cryofibrinogenemia disease disorders hemolytic neurology oncology rhabdomyolysis spinal spinalcord taco
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anemia Clinical ... and petechiae Causes ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
of high parity blood ... without other cause ... symptoms • Fever ... #hematology #diagnosis ... #comparison #table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Clinical Presentation ... Mycoplasma, EBV, HIV ... sensitize red blood ... hemolytic #anemia #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... and clinical associations ... Infections 2. ... #rheumatology # ... comparison #table
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... due to marrow aplasia ... Extremely rare - HIV ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
proteins on plts, leukocytes ... due to marrow aplasia ... Infection - Infection ... #Transfusion #diagnosis ... #management #hematology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... Causes: 1. ... Infections: - ... HIV, CMV, HTLV ... Blockage of the Blood
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
which can plug blood ... Cryofibrinogenemia Symptoms ... Malignancy • Infections ... #rheumatology # ... hematology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Statins - ETOH - Infection ... - Viral (HIV, Influenza ... Dermatomyositis Clinical ... UA positive for blood ... #treatment #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... disease, drug reactions ... to exclude are infections ... Presentation - Systemic Symptoms ... #rheumatology #
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