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diagnosis causes oncology leukemia thrombocytosis chronic cll evaluation extravascular hemolysis intravascular key lymphocytic mds morphology myelodysplasia myelodysplastic nonpalpable palpable platelets
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... uremic syndrome ... , Hematology 2012 ... #Algorithm #Thrombocytopenia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology Atlas ... Thrombotic idiopathic thrombocytopenia ... (ITP), Disseminated ... key #diagnosis #differential ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... #Anemia #Differential ... #workup #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
effect following treatment ... of ITP • Rebound ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... for Thrombotic Thrombocytopenic ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... , thrombocytopenia ... or functional neutropenia ... • Tumor lysis syndrome ... #Leukemia #Hematology
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