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hematology hemolysis algorithm atlas causes intravascular morphology agglutinin bandemia cbc classification cold disease hodgkins key lymphoma management microscopy neutrophil nomenclature
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... elliptocytosis - RBC ... anemia • ... Differential #Diagnosis ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Diseases #Red #BloodCell ... #differential # ... diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... anemia, Thalassemias ... - AST ↑ - Urinalysis ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... bartonella (oroya fever ... #Anemia #Differential ... #workup #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
schistocytes, nucleated RBCs ... anemia Indirect ... count and differential ... a left shift Urinalysis ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... younger pts) Differential ... causing intravascular ... Symptoms: High fevers ... #anemia #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... Neutrophil (Normal) Differential ... tachycardia or fever ... #differential # ... #WBC #CBC #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... classification #hematology
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