41 results
hematopoiesis - leukocyte maturation tree

- Amy Chung, MD, MSc @AmyChung 

#hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology
hematopoiesis - leukocyte ... hematopoiesis #leukocytes ... pathophysiology #Hematology ... Progenitor #Cells #WBC
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings

- Predisposing Factors:  Immunocompromised state, diabetes, elderly, female
urethra), stagnant urine ... Malaise, Incr WBC ... CFU/L) Incr WBC ... (>10 WBC/gL) ... (+) Nitrites, Leukocyte
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... dysmorphic RBCs in urine ... Nephritic #Nephrotic #Syndrome
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria (Negative urine ... • Fanconi's syndrome ... Proteinuria (Positive urine ... sediment - WBC/ ... RBC casts
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
Urinalysis & Urine ... exclusively on urine ... • Ketones • Leukocyte ... Red blood cells (RBC ... dipstick #nitrite #leucocyte-esterase
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... Nephrotic yndrome—podocyte ... Nephritic #Nephrotic #Syndromes
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic sydnrome ... Cellular Casts: • RBC ... glomerulonephritis • WBC ... EricsMedicalLectures/ #Casts #Urine
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
disease - Alport syndrome ... pain hematuria syndrome ... hematuria: - RBC ... - Dysmorphic RBC ... • Nutcracker syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... develop leukostasis syndrome ... AML Dx: • ↑ Leukocyte ... • Tumor lysis syndrome ... #Leukemia #Hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology