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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... or symptoms of liver ... Drug #induced #Liver ... #Diagnosis #Management ... #algorithm #gastroenterology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Differential Diagnosis ... Hepatopathy • Acute ... (Drug-induced liver ... LouLectures #Liver
Evaluation abnormal liver tests in pregnancy
- Cholestatic Pattern
- Hepatocellular Pattern

#LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... Hepatocellular Pattern #LFTs ... obstetrics #hepatology #diagnosis ... #differential # ... algorithm
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatomegaly and anemia ... liver failure ... Liver transplant ... hepatology #hepatitis #differential ... #diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... Renal Disease, Liver ... Reticulocytosis • Liver ... #Diagnosis #Algorithm
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic Anemia ... Hypothyroid • Liver ... #Macrocytic #Anemia ... #differential # ... diagnosis #algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Diagnosis Algorithm ... WBCs - Normal Liver ... Deficiency - Abnormal Liver ... Tests • Liver ... #Diagnosis #Algorithm
Upper GI Bleed - Management Algorithm

Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR
Initial Stabilization
Concern for
Stabilization Concern for Liver ... GAVE (idiopathic, liver ... UGIB #GIBleed #Differential ... #Diagnosis #management ... #gastroenterology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... - Thalassemia, Liver ... Malignant tumors, Acute ... Renal diseases, Liver ... #differential #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... disease, liver ... Cirrhosis #Hepatology #gastroenterology ... #management #diagnosis