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diagnosis hepatology injury causes transaminitis management saag aclf aflp albumin celiac chemistry chronic cirrhosis disease drug druginduced failure fatty function
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver ... LouLectures #Liver
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Drug #induced #Liver ... #algorithm #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Alcohol-related liver ... dechallenge • Acute ... disorder (e.g. ascites ... #Liver #Injury
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... disease, liver ... Injury (DILI) ... Cirrhosis #Hepatology #gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... viral hepatitis ... chemistry #diagnosis #differential ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... diagnosis #algorithm
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Patterns #Liver ... Injury #hepatology #LFTs ... transaminitis #differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Hepatocellular - Liver ... Artery: Shock Liver ... Sophia_Hayes_MD #Liver ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... liver failure rapidly ... develops (DIC, ascites ... Transfer to a liver
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