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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... or symptoms of liver ... Drug #induced #Liver ... #differential # ... #algorithm #gastroenterology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... pathology (low level ... Transaminitis #diagnosis ... #differential #
Focused evaluation algorithm for acute liver injury

#Liver #Injury #Acute #Evaluation #Algorithm #Diagnosis #Hepatology
for acute liver ... injury #Liver ... #Injury #Acute ... #Evaluation #Algorithm ... #Diagnosis #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Liver Failure ( ... disease, liver ... Injury (DILI) ... Cirrhosis #Hepatology #gastroenterology ... #management #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... diagnosis #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Cirrhosis • Chronic ... (Drug-induced liver ... injury) • Ischemic ... LouLectures #Liver
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
Diagnosis Algorithm ... Traumatic brain injury ... Hypoxia, Uremia, Liver ... #Diagnosis #Algorithm ... #Causes #neurology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... : Liver Injury ... Injury Differential ... #Injury #Differential ... #algorithm #Transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Alcohol-related liver ... cholangitis Consider liver ... #DrugInduced #Liver ... #Injury #Diagnosis
Table of Causes of Acute Liver Injury
#Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Causes of Acute Liver ... Injury #Diagnosis ... Hepatology #Acute #Liver ... #Injury #Causes ... #Differential #