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diagnosis differential hepatology management causes injury acute bariatric chronic cirrhosis complications dili rheumatology surgery transaminitis abdominal abnormal aclf bloating bypass
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... months without treatment ... disease, liver ... support, or liver ... Cirrhosis #Hepatology #gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... obstruction, HELLP Syndrome ... Artery: Shock Liver ... Causes #Acute #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... disease: > 2 ... • Gilbert's syndrome ... transaminitis #LFTs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver ... #algorithm #gastroenterology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
- Diagnosis Algorithm ... unresponsive to treatment ... • Elevated liver ... autoimmune thyroiditis, hepatitis ... #gastroenterology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's Disease ... • Budd-Chiari Syndrome ... Differential #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... #injury #hepatitis ... differential #diagnosis #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... Alcohol-related liver ... disease, Hepatic ... #DrugInduced #Liver
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