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Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... DILI and Type of Liver ... LiverInjury #Hepatology #Pharmacology ... #Causes #DILI
The Gastroenterology Consult Primer
Guide to Calling a GI Consult
HPI:
 - Start with reason for consult
consult - I-liner ... lipase PMH: - Focus ... on prior GI/Liver ... last meal - Treatment ... GregoryTBrennan #Liver
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
diagnosis and treatment ... symptoms, elevated liver ... is >1,000 μg/L, liver ... A liver biopsy can ... of liver disease
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Acute Fatty Liver ... Hemolysis, Elevated Liver ... exchange 3) Fatty liver ... coagulation defects and liver ... diagnosis #table #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Hemolysis, Elevated Liver ... child * Severe cases ... exchange 2) Fatty liver ... coagulation defects and liver ... Hematology #Diagnosis #Comparison
Liver Abscess
•	Pyogenic abscess, accounts for 80% of abscess.
•	Amebic abscess due to Entamoeba histolytica, accounts for 10%.
•	Fungal
Liver Abscess • ... 50% of solitary liver ... occur in the right Liver ... the bacterial cases ... #liverabscess #liver
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... for alternative causes ... Alcohol-related liver ... #DrugInduced #Liver
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... gluconeogenesis by the liver ... agent • Does not cause ... m2 • Severe liver ... #Metformin #Pharmacology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
production • Treatment ... rapidly fatal • Causes ... Identify underlying cause ... Cooling blankets can cause ... #Hyperthermia #comparison
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... Contrast #CT #MRI #POCUS ... differential #diagnosis #comparison