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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus ... #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
- Differential ... Disease: Systemic Lupus ... Erythematous, Systemic ... #arthritides #Differential ... #Diagnosis #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... lesions • Discoid lupus ... erythematosus ... #skin #rashes #differential ... #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... Juvenile Idiopathic Arthritis ... erythematosus ( ... ANA #patterns #rheumatology ... #diagnosis #differential
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Pleuritis) H Hematologic ... cytopenias) A Arthritis ... #erythematosus ... #rheumatology #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Erythematosus ... Constitutional domain: Fever ... • Arthritis domain ... #Erythematosus ... #diagnosis #rheumatology
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
Pediatrics Patient - Differential ... Suggestive of: Lupus ... Suggestive of: Rheum Fever ... gabrieltalledop #dermatology ... #differential #
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver ... Macrocytic #Anemia #differential ... diagnosis #algorithm #hematology ... #workup
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... Malar rash 40% - Fever ... #Erythematosus ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... #Diagnosis #Rheumatology