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hematology differential management treatment hemophagocytic lymphohistiocytosis oncology skin syndrome anemia comparison workup classification disease erythematosus infection lupus reactions sle table
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
) Clinical Features ... : Fever, Splenomegaly ... IL-2 receptor Diagnostic ... 8 criteria: • Fever ... #hematology #criteria
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... #Management #Hematology ... #Rheumatology
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... If fever is present ... but without a fever ... #Diagnosis #Dermatology ... #Febrile #Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Diagnosis via genetic ... following: • Fever ... lymph node, or liver ... management #treatment #hematology
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... Algorithm Pathophysiology ... instability - New-onset fever ... with rash - Mucocutaneous ... #Dermatology #Rash
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... Alloimmune • anti-HLA ... #Algorithm #Causes ... #Hematology
Vibrio Vulnificus skin infection Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. Vibrio vulnificus part of
marine microbiota & causes ... Rapid onset of fever ... #cellulitis #dermatology ... #legs #clinical ... #photo
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH Vesiculobullous rashes provoke significant angst in many physicians (Figure 5, page
Vesiculobullous Rashes - THE ALGORITHMIC ... and a fever may ... localized lesions and fever ... #Diagnosis #Dermatology ... #Algorithm #Differential
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Algorithmic Approach ... triad (<10%): fever ... , rash, eosinophilia ... Nephritis #AIN #Algorithm ... #nephrology #diagnosis
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