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Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level ... Histopathologic criteria
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... for Systemic Lupus ... Constitutional domain: Fever ... least 2 joints • Neurologic ... pericarditis • Hematologic
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... Mono (EBV, CMV), Acute ... Medicine @SCVMCMed #Fever ... #Diagnosis #dermatology
NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness
NINDS Diagnostic Criteria ... dysfunction, Absence of fever ... Central nervous system ... hexacarbon abuse • Acute ... #neurology #neuropathy
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... • Acute disseminated ... • Systemic lupus ... #neurology #inflammatory ... #differential #
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Cough, Dyspnea, Fever ... symptomatology Differential ... Immune Complex: Systemic ... #differential # ... diagnosis #nephrology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
for Sweet Syndrome ... (Acute Febrile ... Fever, temperature ... treatment with systemic ... #Acute #Febrile
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Lung Diseases • Acute ... initiation of smoking; Fever ... brown sputum, fever ... Hypereosinophilic Syndrome ... Travel hx, food hx; Fever
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
papilledema • Horner syndrome ... pupil (AACG) • Systemic ... and signs (e.g., fever ... arteritis • Acute ... Diagnosis #Algorithm #neurology
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Workup for Hyperphosphatemia ... - Differential ... t-PA, heparin Acute ... Rhabdomyolysis, Tumor lysis syndrome ... #phosphate #nephrology