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diagnosis hematology management anemia oncology algorithm blood causes product reactions workup agglutinin aids apml atlas bloodcell chronic classification cll cns
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Approach to Anemia - Differential ... -100): • Non-hemolytic ... : ACD, Aplastic ... Non-megaloblastic: Liver ... #Diagnosis #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... megaloblastic anemia Treatment ... if neutropenic fever ... Medicine @SCVMCMed #Aplastic ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... bartonella (oroya fever ... Consider RBC membrane disorder ... #Anemia #Differential ... Algorithm #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... mountain spotted fever ... #Diagnosis #hematology ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... index < 2 • EPO Level ... anemia Treatment ... Anemia #oncology #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Unstable hemoglobin disorders ... Cold autoimmune hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... younger pts) Differential ... Symptoms: High fevers ... #anemia #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... due to marrow aplasia ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... due to marrow aplasia ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... initiation • Differential ... Renal Failure Treatment ... diagnosis #management #hematology
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