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management causes dermatology algorithm disease symptoms syndrome oncology treatment erythematosus lupus sle workup comparison arthritis hemophagocytic lymphohistiocytosis pain systemic anemia
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
) Clinical Features ... : Fever, Splenomegaly ... Criteria for HLH ... : • Fever • Splenomegaly ... #hematology #criteria
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... : HLH signs and ... following: • Fever ... lymph node, or liver ... management #treatment #hematology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
: - Fever >= 39C ... with concomitant fever ... Abnormalities in liver ... #Diagnosis #Major ... #Minor #Rheumatology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
Diagnostic criteria ... 30mm length) • Fever ... >38.3°) Minor Criteria ... Enterocolitis #Diagnosis ... #criteria #hematology
Acute Fever in-from the Tropics - Clinical Examination #Tropics #Traveler #Fever #Differential #Signs #Diagnosis #InfectiousDiseases
Acute Fever in-from ... the Tropics - Clinical ... Tropics #Traveler #Fever ... #Differential # ... Signs #Diagnosis
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
Faget's Sign & Liebermeister's ... CLINICAL UTILITY ... #Fagets #Sign #Pulse ... #Dissociation #diagnosis ... #differential #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... treatment #summary #rheumatology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Fever of Unknown ... Refer to your ‘Fever ... thin smear • Signs ... node biopsy • Clinical ... udaygulati #FUO #Fever
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... If fever is present ... disease, scarlet fever ... but without a fever ... #Diagnosis #Dermatology
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