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diagnosis management hematology arthritis causes disease erythematosus hemophagocytic hlh infections lymphohistiocytosis sle summary syndrome systemic classification fungal infectiousdiseases meningitis adultonset
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... nervous system (CNS ... #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE) Clinical ... Puncture, EEG Treatment ... Erythematosus #SLE #CNS ... #neurology #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Erythematosus Clinical ... Constitutional domain: Fever ... least 2 joints • Neurologic ... Erythematosus #diagnosis #rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... should be based on clinical ... Antimicrobial treatment ... • Symptoms: Fever ... • Symptoms: Fever
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... weight loss, and fever ... permanent alopecia Differential ... to: Arthritis, Fever ... Chronic B-cell activation
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... sequestration and activation ... explain symptoms • Fever ... : 33% • Treatment ... pulmonary edema) • Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... #summary #rheumatology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... • Headache • Fever ... • Common clinical ... meningeal signs (fever ... Singh @rav7ks #CNS
13 Dangerous Causes of Headache: - subarachnoid hemorrhage: family history, PCKD, known berry aneurysm, sudden and
hypertension - CNS ... infection: fever ... at home or at work ... thrombophilia, neurologic ... Dangerous #Deadly #Differential
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... following: • Fever ... • Bicytopenia Treatment ... #hematology
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