28 results
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... Supportive with treatment ... cholestasis: • Fever ... #differential # ... diagnosis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... #Injury #Differential ... #Diagnosis #Causes ... #Acute #algorithm
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Injury Transaminase ... > 20x normal - Acute ... normal - Hemolysis, NASH ... transaminitis #differential ... #diagnosis
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... to Acute Interstitial ... triad (<10%): fever ... , rash, eosinophilia ... #nephrology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #injury #hepatitis ... diagnosis #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... non-essential drug/HDS treatments ... dechallenge • Acute ... #Injury #Diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
viral hepatitis ... viral hepatitis ... disease: > 2 • NASH ... #chemistry #diagnosis ... #differential #
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
injury 4. ... Presentation: - Fever ... , Rash, Myalgias ... Low voltage Treatment ... #Myocarditis #diagnosis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... : • Early acute ... hepatitisAcute ... myocarditis, rheumatic fever
Causes of Acute Pericarditis:

Infectious;

Viral: 
Adenovirus 
Coxsackie virus A and B 
Echovirus 
Epstein-Barr virus 
Hepatitis 
Human immunodeficiency
Epstein-Barr virus Hepatitis ... Mediterranean fever ... granulomatosis Rheumatic fever ... #Pericarditis #Differential ... #Diagnosis