159 results
Proposed Treatment Algorithm for MAS / HLH

#MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Proposed Treatment ... Algorithm for MAS ... / HLH #MAS # ... HLH #Hemophagocytic ... #Algorithm #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... Clinical Features: Fever ... lab findings in HLH ... 8 criteria: • Fever ... Lymphohistiocytosis #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
signs and symptoms ... following: • Fever ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
HLH 2. ... Hyperferritinemia #Algorithm ... Differential #Diagnosis #Hematology
Algorithmic Guide to Tick-Borne Illnesses in the United States - By Major Symptoms (Fever, Rash, Lymphadenopathy)
Algorithmic Guide ... States - By Major Symptoms ... (Fever, Rash, Lymphadenopathy ... Illnesses #TBI #Guide #Algorithm ... Region #Ticks #Fever
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Dengue Fever - Diagnosis and Management Summary 
Dengue Fever → Dengue Hemorrhagic Fever →Dengue Hemorrhagic Shock
Dengue Fever - Diagnosis ... Summary Dengue Fever ... Dengue Hemorrhagic Fever ... Presentation: Fever ... 7 days (Ig)M Treatment
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
HLA-DR4 mutation ... GCA is almost never ... old; F>M Signs/Symptoms ... : - Fever - ... Diagnosis #Signs #Symptoms
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... Supportive with treatment ... cholestasis: • Fever ... Liver transplant ... Hepatobiliary #hepatology