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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... Vesicopustule on erythematous ... Discoid lupus erythematosus ... #skin #rashes #differential ... #diagnosis #rheumatology
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
or absence of fever ... If fever is present ... disease, scarlet fever ... but without a fever ... Nikolsky #Febrile #Fever
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level ... #Hematology #Rheumatology
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
, Typhoid fever, ... , Dengue fever, ... , Drug fever ... bradycardia #Causes #differential ... infectiousdiseases #table
Rodent-associated Bacterial infections: Leptospirosis, Rat-bite fever, Tularemia, Plague 

#rodent
#infections
#leptospirosis
#tularemia
#ratbitefever
#plague
#rats
#infectiousdisease
#fever
#differential
#diagnosis
#management
#treatment
#table
Leptospirosis, Rat-bite fever ... infectiousdisease #fever ... #differential ... #diagnosis #management ... #treatment #table
Differential Diagnosis - Fever of Unknown Origin (FUO)

IMADE mnemonic:
 • Infection
 • Malignancy
 • Autoimmune (Rheumatologic)
Differential Diagnosis ... - Fever of Unknown ... • Autoimmune (Rheumatologic ... udaygulati #FUO #Fever ... UnknownOrigin #Differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Malar rash 40% - Fever ... (aPL) 30-45% Differential ... Systemic #Lupus #Erythematosus ... #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Systemic Lupus Erythematosus ... Constitutional domain: Fever ... pericarditis • Hematologic ... Systemic #Lupus #Erythematosus ... #diagnosis #rheumatology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... cholestasis: • Fever ... Liver transplant ... Hepatobiliary #hepatology ... #hepatitis #differential