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diagnosis differential management causes erythematosus hematology sle symptoms systemic activation aortic clinical echocardiogram effusion infectiousdiseases leukostasis lysis macrophage mas pericardial
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... effusion, Restrictive lung ... Demyelinating syndromes ... Pericarditis, Endocarditis ... erythematosus #signs
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... rash) • Heart, lung ... #Rheumatology
Causes of Severe Aortic Regurgitation - Differential Diagnosis Acute: • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Acute Infective Endocarditis ... , Rheumatic Fever ... Inflammatory: Lupus ... Ehlers-Danlos Syndrome ... Diagnosis #Causes #cardiology
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Non-Infectious: • Rheumatologic ... Mediterranean Fever ... Disease, Behcet Syndrome ... - Metastatic: Lung ... Diagnosis #Causes #cardiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... - 80% have fever ... WBC >100k, + lab signs ... organ damage • Treatment ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Non-autoimmune rheumatologic ... • Libman-Sacks endocarditis ... to: Arthritis, Fever ... Erythematosus #Diagnosis #Rheumatology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
e.g. incidental CXR ... General: fever, ... skin (16-32%): lupus ... : ACUTE, fever, ... presentation with fever
Tricuspid Valve Endocarditis on POCUS Echocardiogram Patient with active IVDU presents with fever, sepsis. More likely
Tricuspid Valve Endocarditis ... presents with fever ... frequently have lung ... emboli (see CT cor ... Echocardiogram #clinical #cardiology
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 Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
, verrucous) - Lung ... night sweats, fever ... Cholesterol emboli syndrome ... hematuria, + RF Treatment ... Differential #Diagnosis #cardiology
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