38 results
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... Macrocytic #Anemia #differential ... diagnosis #algorithm #hematology ... #workup
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
acute rheumatic fever ... ), RA, crystal disease ... #rheumatology # ... approach #workup ... #differential #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... • Rheumatic fever ... Sarcoidosis #dermatology ... #rashes #differential ... #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... • New murmur, fever ... #pain #differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... bartonella (oroya fever ... Hemolytic #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... fraction < 20% Differential ... diagnosis #management #treatment ... #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... mountain spotted fever ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Diagnosis #Management #Hematology ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... - Autoimmune Rheumatologic ... • Rheumatic fever ... streptococci (rheumatic fever ... #pain #Differential